Growth Retardation during Organogenesis in Genetically Diabetic Mice, Yellow KK

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  • Growth retardation during organogenesis

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SUMMARY Yellow KK mice with non-insulin dependent diabetes were mated at 7 (group A) or 13 (group B) weeks of age. On day 13, 16, or 18 of pregnancy, the plasma glucose concentration in dams was determined, and the embryos/fetuses and placentae were weighed and examined. The rate of early embryonic death was high and invariable on all three days. The rate of late death increased with advancing pregnancy in both groups and the incidence in group B was higher than in group A on each of the three days. On day 13 of pregnancy, maternal plasma glucose concentration in group B was significantly higher than in group A (465 mg/dl vs 230 mg/dl). Embryonic and placental weights in group B were less than those in group A (84 vs 113 mg and 59 vs 68 mg). In group B, there was an inverse correlation between the maternal plasma glucose concentration and the embryonic weight. A similar inverse correlation existed between the maternal plasma glucose concentration and the placental weight. On days 16 and 18 of pregnancy, fetal weights in group B were less than those in group A, but placental weights did not differ significantly be- tween the two groups. From these results, it appears that in the yellow KK mouse fetal growth retardation has already begun in the organogenesis period and is closely related to maternal hyperglycemia.

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