Induction of Cardiovascular Malformations by Leupeptin in the Rat

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  • Induction of cardiovascular malformatio

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Abstract

ABSTRACT The teratogenic effects of leupeptin on the rat embryonic heart were exa- mined. Wistar rats were injected with 30 mg/kg of leupeptin, 50 mg/kg of leupeptin, and 2.5 ml/kg of normal saline (control group) on days 9 and 10 of gestation. Term fetal weight was significantly lower in the leupeptin groups than in controls. At leupeptin 30 mg/kg, the resorption rate, incidence of malformation, and incidence of cardiovascular (CV) malformation were 13.2070, 34.8'70, 16.7'70, respectively. At leupeptin 50 mg/kg, the resorption rate, incidence of malformation, and incidence of CV malformation were 19.7%, 81.4070, 36.3'70, respectively. The most common malformations were hydrocephaly, anophthalmia, microphthalmia, VSD, ASD, hydronephrosis, and diaphragmatic hernia. Multiple organ systems were affected. Malformation types were similar to those induced by anti-kidney antiserum (AKS) and trypan blue (TB).

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