Experimental Hydrocephalus in Suckling Hamster Induced by Myxovirus Infection: Pathogenesis of Hydrocephalus Caused by Parainfluenza Virus Type 3

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  • Experimental hydrocephalus in suckling hamster induced by myxovirus infection-2-Pathogenesis of hydrocephalus caused by parainfluenza virus type 3
  • Experimental hydrocephalus in suckling
  • Experimental Hydrocephalus in Suckling Hamster Induced by Myxovirus Infection

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Abstract

ABSTRACT Intraperitoneal inoculation of suckling hamsters with parainfluenza virus type 3 (PIV-3) caused hydrocephalus in about 17% of animals thus treated. In the inoculated hamsters, the PIV-3 antigen was found to be located in the choroid plexus and ependymal cells of the ventricular system. This finding suggests that the PIV-3 inoculated intraperitoneally transferred to the choroid plexus from the blood stream and invades this tissue first, and then gradually affects the ependymal cells of the ventricular system. The pathologic findings obtained in this experiment showed a close similarity with those obtained in our previous experiment on mumps virus induced hydrocephalus. It was conjectured that PIV-3 induced hydrocephalus was caused by the same pathogenesis with the hydrocephalus by mumps virus infection. Our results strongly suggest that the PIV is a probable candidate for human congenital hydrocephalus of unknown origin, since PIV is the most common myxovirus.

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