Disruption of brain development in male rats exposed prenatally to 5‐bromo‐2‘‐deoxyuridine
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- タイトル別名
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- Disruption of brain development in male rats exposed prenatally to 5-bromo-2‘-deoxyuridine
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ABSTRACT Sprague-Dawley rats were treated intraperitoneally with 5-bromo-2′-deoxyuridine (BrdU) at 0,12.5 or 50 mg/kg/day on days 9 through 15 of gestation to evaluate the effects on development of the brain of offspring. Prenatal exposure to BrdU induced abnormal development of the brain; dilatation of the lateral ventricles in male offspring in the postnatal period. The ratio of the length of the longitudinal fissure to that of the cerebral cortex decreased in a dose-dependent manner in the embryonic period and thereafter. In 14-week-old male offspring exposed prenatally to BrdU at 50 mg/kg, the cortex layer of the cerebrum was thinner than that of the controls. Masculine sexual behavior was markedly impaired and the volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) was decreased in the 50 mg/kg group as compared with the controls. These results demonstrate that prenatal exposure to BrdU affected the development of the brain hi the prenatal and postnatal stages and reduced the volume of SDN-POA after puberty, resulting in a disruption of reproductive ability in male rats.
収録刊行物
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- 日本先天異常学会会報
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日本先天異常学会会報 41 (4), 312-320, 2001
日本先天異常学会
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詳細情報 詳細情報について
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- CRID
- 1390007447387312128
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- NII論文ID
- 110002785934
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- NII書誌ID
- AN10066760
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- ISSN
- 09143505
- 24331503
- 17414520
- 00372285
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- NDL書誌ID
- 6047241
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- Web Site
- http://id.ndl.go.jp/bib/6047241
- https://ndlsearch.ndl.go.jp/books/R000000004-I6047241
- https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1741-4520.2001.tb00841.x
- https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1741-4520.2001.tb00841.x
- https://search.jamas.or.jp/link/ui/2002183864
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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