Development of the method to identify adducts formed by NAC/NAL and test substances, and oxidation products of NAC in ADRA reaction solutions by high-resolution LC-MS analysis

DOI

Bibliographic Information

Other Title
  • 高分解能LC-MSを用いたADRA反応液中のNAC/NAL付加体及びNAC酸化物の網羅的検出法の開発

Abstract

<p>ADRA is an alternative test for skin sensitization using cysteine and lysine derivatives (NAC and NAL) to evaluate the reactivity of chemicals with these reagents. However, since the sensitization potential is decided only by NAC/NAL depletion in this test, it is unclear whether these depletions are truly occurred by reaction with chemicals. We developed the method to identify adducts formed by NAC/NAL and chemicals, and oxidation products of NAC in reaction solutions by LC-MS analysis. We believe this method is useful for differentiating between true and false positive results in ADRA.</p>

Journal

Details 詳細情報について

  • CRID
    1390007536267656576
  • NII Article ID
    130008073684
  • DOI
    10.14869/toxpt.48.1.0_p-161e
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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