Development of the method to identify adducts formed by NAC/NAL and test substances, and oxidation products of NAC in ADRA reaction solutions by high-resolution LC-MS analysis
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- KAMIYA Kohei
- Nissan Chemical Corporation
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- MISAWA Yasushi
- Nissan Chemical Corporation
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- SUGIHARA Mamoru
- ALBION Co., Ltd
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- NAKASHIMA Megumi
- ALBION Co., Ltd
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- TAKEUCHI Kazuya
- Nissan Chemical Corporation
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- FURUKAWA Satoshi
- Nissan Chemical Corporation
Bibliographic Information
- Other Title
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- 高分解能LC-MSを用いたADRA反応液中のNAC/NAL付加体及びNAC酸化物の網羅的検出法の開発
Abstract
<p>ADRA is an alternative test for skin sensitization using cysteine and lysine derivatives (NAC and NAL) to evaluate the reactivity of chemicals with these reagents. However, since the sensitization potential is decided only by NAC/NAL depletion in this test, it is unclear whether these depletions are truly occurred by reaction with chemicals. We developed the method to identify adducts formed by NAC/NAL and chemicals, and oxidation products of NAC in reaction solutions by LC-MS analysis. We believe this method is useful for differentiating between true and false positive results in ADRA.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-161E-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390007536267656576
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- NII Article ID
- 130008073684
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed