Application of adult toxicity prediction system using human ESCs

DOI
  • YAMANE Junko
    Center for iPS Cell Research and Application, Kyoto University
  • OTSUKI Hironori
    Translational Research Unit, R&D Division, Kyowa Kirin Co., Ltd.
  • INOMATA Koji
    Translational Research Unit, R&D Division, Kyowa Kirin Co., Ltd.
  • SUZUKI Mutsumi
    Translational Research Unit, R&D Division, Kyowa Kirin Co., Ltd.
  • SONE Hideko
    Environmental Health and Prevention Research Unit, Yokohama University of Pharmacy
  • FUJIBUCHI Wataru
    Center for iPS Cell Research and Application, Kyoto University

Bibliographic Information

Other Title
  • ヒトES細胞を用いた化学物質毒性予測系の成人毒への適用

Abstract

<p>We reported a high accuracy toxicity prediction system using human ES cells in 2016. As next challenges, we report the results of an attempt to apply it to the adult toxins such as nephrotoxins, neurotoxins, and hepatotoxins. Toxicity prediction was performed using gene expression data of about 20 chemicals in human ES cells, and it was found that, for example, hepatotoxins can be predicted with a high accuracy of 90.5%. This prediction system, which uses human ES cells as a reaction device for chemicals, can apply mixtures that have been difficult to predict, and can be used as an unknown primary toxicity screening. As the number of chemicals increases in the future, it is expected that the effects of machine learning will be progressed and the prediction system will become more robust.</p>

Journal

Details 詳細情報について

  • CRID
    1390007536267678976
  • NII Article ID
    130008073805
  • DOI
    10.14869/toxpt.48.1.0_s13-2
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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