Early life exposure to acephate exerts the neurobehavior and gut microbiota in adult mice

DOI
  • SASAKI Takahiro
    Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
  • HASEGAWA Ayano
    Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
  • SAKAI Kazuya
    Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
  • HIRADATE Yuuki
    Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
  • HARA Kenshiro
    Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
  • ISLAM Jahidul
    Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University
  • NOCHI Tomonori
    Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University
  • TANEMURA Kentaro
    Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University

Bibliographic Information

Other Title
  • アセフェートの発生-発達期慢性ばく露による成熟後のマウス行動影響と腸内細菌叢の解析

Description

<p>Acephate (Ace), an organophosphate insecticide, is also toxic to mammals. In this study, we examined the effects of chronic Ace exposure in early life on the brain functions and gut microbiota in adult male and female mice, including acceptable daily intake (ADI) level concentrations. These results suggested that chronic exposure to Ace during the early developmental stages, even at ADI level concentrations, leads to neurobehavioral diseases and disruption of the gut microbiota. The correlation between Ace-induced behavioral effects and an altered microbiome will be further investigated.</p>

Journal

Details 詳細情報について

  • CRID
    1390007536268256768
  • NII Article ID
    130008073586
  • DOI
    10.14869/toxpt.48.1.0_p-107s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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