Early life exposure to acephate exerts the neurobehavior and gut microbiota in adult mice
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- SASAKI Takahiro
- Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
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- HASEGAWA Ayano
- Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
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- SAKAI Kazuya
- Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
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- HIRADATE Yuuki
- Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
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- HARA Kenshiro
- Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
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- ISLAM Jahidul
- Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University
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- NOCHI Tomonori
- Laboratory of Functional Morphology, Graduate School of Agricultural Science, Tohoku University
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- TANEMURA Kentaro
- Laboratory of Animal Reproduction and Development, Graduate School of Agricultural Science, Tohoku University
Bibliographic Information
- Other Title
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- アセフェートの発生-発達期慢性ばく露による成熟後のマウス行動影響と腸内細菌叢の解析
Description
<p>Acephate (Ace), an organophosphate insecticide, is also toxic to mammals. In this study, we examined the effects of chronic Ace exposure in early life on the brain functions and gut microbiota in adult male and female mice, including acceptable daily intake (ADI) level concentrations. These results suggested that chronic exposure to Ace during the early developmental stages, even at ADI level concentrations, leads to neurobehavioral diseases and disruption of the gut microbiota. The correlation between Ace-induced behavioral effects and an altered microbiome will be further investigated.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-107S-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390007536268256768
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- NII Article ID
- 130008073586
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed