Involvement of Sox9 in liver fibrosis of non-alcoholic steatohepatitis (NASH) dietarily induced in mice

DOI
  • NAKANE Sae
    Department of Nutritional Science and Food Safety, Graduate School of Applied Bioscience, Tokyo University of Agriculture
  • KEMURIYAMA Noriko
    Department of Nutritional Science and Food Safety, Faculty of Bioscience, Tokyo University of Agriculture
  • ABE Akari
    Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture
  • YUKI Megumi
    Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture Advantec Co.,Ltd. Pathology Department
  • UNO Kinuko
    Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
  • OGAWA Syuji
    Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
  • SANO Ryuhei
    Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
  • WATANABE Atushi
    Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
  • TAKASU Shinji
    Division of Pathology, National Institute of Health Science
  • UMEMURA Takashi
    Division of Pathology, National Institute of Health Science Faculty of Animal Health Techolorgy, Yamazaki University of Animal Health Techology
  • MIYAJIMA Katuhiro
    Department of Nutritional Science and Food Safety, Graduate School of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, Faculty of Bioscience, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture
  • NAKAE Dai
    Department of Nutritional Science and Food Safety, Graduate School of Applied Bioscience, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, Faculty of Bioscience, Tokyo University of Agriculture Department of Nutritional Science and Food Safety, Graduate School of Agriculture, Tokyo University of Agriculture Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture

Bibliographic Information

Other Title
  • マウス食餌性非アルコール性脂肪肝炎（NASH）モデルの線維化におけるSox9の関与に関する研究

Abstract

<p>The present study aimed to clarify whether a bile ductular reaction induces liver fibrosis in the dietarily induced mouse NASH model, using the expression of SRY-box9 (Sox9) as a biomarker. In the liver of mice fed a special CDAHFD-0.1 diet for 14 days, steatosis became remarkable with slight fibrosis, and the extra-bile duct Sox9 expression was observed. At the end of week 13, fibrosis became prominent, and the Sox9 expression was marked and diffuse. In conclusion, the Sox9 expression may not be a consequence of NASH-derived liver fibrosis, but involved in its development and progression. </p>

Journal

Details 詳細情報について

  • CRID
    1390007536268344448
  • NII Article ID
    130008073832
  • DOI
    10.14869/toxpt.48.1.0_p-50s
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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