Pregnant rats exposed to low level methylmercury exhibit cerebellar synaptic and neuritic remodeling during the perinatal period

DOI

Bibliographic Information

Other Title
  • 低濃度メチル水銀の妊娠期曝露はラット母体脳において神経軸索およびシナプスの再形成を引き起こす

Abstract

<p>Exposure of pregnant rats to low level MeHg induced cerebellar synaptic and neuritic remodeling during the perinatal period. We identified suppression of the TrkA pathway and reduced Arc expression in MeHg-exposed pregnant rats during the perinatal period. MeHg-exposed pregnant rats also exhibited increased perinatal plasma corticosterone levels and decreased estradiol levels. These results suggest that exposure of pregnant rats to low level MeHg affected perinatal cerebellar synaptic and neuritic remodeling through modulation of the TrkA pathway and Arc expression which may be caused by MeHg-induced hormonal changes.</p>

Journal

Details 詳細情報について

  • CRID
    1390007536268913792
  • NII Article ID
    130008073598
  • DOI
    10.14869/toxpt.48.1.0_o-8
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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