Phenotyping of cytochrome P450 3A enzymes in individual cynomolgus monkeys by endogenous compounds in plasma determined by liquid chromatography-mass spectrometry
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- NAKANISHI Yasuharu
- Shin Nippon Biomedical Laboratories, LTD.
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- IEKI Katsunori
- Shin Nippon Biomedical Laboratories, LTD.
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- KAMIMORI Hiroshi
- Shin Nippon Biomedical Laboratories, LTD.
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- NAKAMURA Takatoshi
- Shin Nippon Biomedical Laboratories, LTD.
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- UTOH Masahiro
- Shin Nippon Biomedical Laboratories, LTD. Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
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- YAMAZAKI Hiroshi
- Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University
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- TSUSAKI Hideshi
- Shin Nippon Biomedical Laboratories, LTD. Biomedical Research Laboratory, Gifu Pharmaceutical University
Bibliographic Information
- Other Title
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- 液体クロマトグラフ-質量分析法による血漿中の内因性物質濃度を指標としたカニクイザル個体のチトクロムP450 3A表現型解析
Abstract
<p>Recently, the endogenous compounds 4β-hydroxycholesterol (4β-OH-CHO) and 6β-hydroxycortisol (6β-OH-COR) have been found to be biomarkers of CYP3A in human and monkey. In this study, we developed a method for determining 4β-OH-CHO, cholesterol, 6β-OH-COR, and cortisol concentrations in monkey plasma. After a sensitive LC-MS/MS method was developed and validated, the individual monkey plasma was measured. We will introduce information on the endogenous biomarkers of CYP3A activity in individual monkey plasma and discuss basic information on this evaluation method.</p>
Journal
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- Annual Meeting of the Japanese Society of Toxicology
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Annual Meeting of the Japanese Society of Toxicology 48.1 (0), P-142-, 2021
The Japanese Society of Toxicology
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Details 詳細情報について
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- CRID
- 1390007536269464192
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- NII Article ID
- 130008073706
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed