Establishment of test method and validation of evaluation criteria for high sensitivity miniaturized Ames test

DOI

Bibliographic Information

Other Title
  • 高感度小型化Ames試験の試験方法の確立と評価基準の検証

Description

<p>Evaluation of Ames test with small amount of sample is requested not only for pharmaceutical impurities and early stage drugs, but also for compounds that are difficult to synthesize or expensive. In this study, we used 24 well plate as a miniaturized Ames test and compared it with the existing test methods for four strains of TA100, TA98, TA97 and WP2 uvrA/pKM101. We report on the optimal test design for miniaturized Ames tests, the consistency of miniaturized Ames tests with existing test methods, evaluation methods, and usefulness for pre-incubation methods for miniaturized Ames tests.</p>

Journal

Details 詳細情報について

  • CRID
    1390007536269502080
  • NII Article ID
    130008073781
  • DOI
    10.14869/toxpt.48.1.0_p-97
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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