An Epidemic Case of Rabbit Hemorrhagic Disease Caused by Rabbit Hemorrhagic Disease Virus 2 （<i>Lagovirus europaeus</i> GI.2） in Tochigi, Japan

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  • 国際的に流行するRHDV2（<i>Lagovirus europaeus</i> GI.2）による 兎出血病の国内発生例
  • 国際的に流行するRHDV2 (Lagovirus europaeus GI.2)による兎出血病の国内発生例
  • コクサイテキ ニ リュウコウ スル RHDV2 (Lagovirus europaeus GI.2)ニ ヨル ウサギ シュッケツビョウ ノ コクナイ ハッセイレイ

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Abstract

<p>　In May 2020, eleven out of fifteen domestic rabbits (Oryctolagus cuniculus) kept at an animal exhibition facility in Tochigi Prefecture suddenly died during a period of nine days. Most rabbits did not show any clinical symptoms, but gross necropsy examination revealed severe pulmonary hemorrhage in the dead rabbits. Histopathological examination in four of the dead rabbits demonstrated hepatocyte necrosis and disseminated intravascular coagulation in the kidney and lung. RHDV genome was detected in the liver and/or spleen collected from the four dead rabbits. Phylogenetic analysis based on partial VP60 sequence classified the detected RHDV into RHDV2 (Lagovirus europaeus GI.2). Based on these findings, the case was diagnosed as rabbit hemorrhagic disease due to infection of RHDV2.</p>

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