Development of Transdermal Vaccines for Pollinosis Immunotherapy Using Oil Based Nanodispersion Carriers Containing Antigen Epitopes
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- Goto Masahiro
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University Advanced Transdermal Drug Delivery System Center, Kyushu University
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- Higashijima Koki
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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- Kitaoka Momoko
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
Bibliographic Information
- Other Title
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- 抗原エピトープ封入油状ナノキャリアを用いた 花粉症経皮ワクチンの開発
- コウゲン エピトープ フウニュウ ユジョウ ナノキャリア オ モチイタ カフンショウ ケイヒ ワクチン ノ カイハツ
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Description
In recent years, pollinosis immunotherapy has been attracting much attention, however, the administration methods of vaccine drugs have been limited to the subcutaneous injection or the sublingual administration. In this study, we developed a transdermal vaccine administration strategy for the simple and non–invasive pollinosis immunotherapy. For the transdermal antigen delivery, the presence of stratum corneum, the hydrophobic outermost layer of the skin, is an obstacle. Another problem with current pollinosis immunotherapy is side effects of using the whole allergen molecules. To overcome these issues, we applied a solid–in–oil (S/O) nanodispersion, which is composed of hydrophilic antigen molecules coated with hydrophobic surfactants, and enables transdermal penetration of the antigen molecules into the skin. In addition, we introduced a T cell epitope peptide derived from the cedar pollen allergen (PepA : SMKVTVAFNQFGP), which had shown lower risks of the side effects. We succeeded in preparing an S/O nanodispersion containing PepA. The oil–based S/O system enhanced the skin penetration of the PepA. Antigen specific IgE levels in the murine models were significantly reduced by the S/O administration. Activations of the type–1 helper T and regulatory T cells were also confirmed, which indicates the effectiveness of the pollinosis immunotherapy using the S/O vaccine system.
Journal
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- MEMBRANE
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MEMBRANE 46 (4), 226-232, 2021
THE MEMBRANE SOCIETY OF JAPAN
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Details 詳細情報について
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- CRID
- 1390007670440153600
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- NII Article ID
- 130008077387
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- NII Book ID
- AN0023215X
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- ISSN
- 18846440
- 03851036
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- NDL BIB ID
- 031636898
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed