Generational Study of Laryngeal Cancer Cases―Comparison of Middle-Aged, Early-Stage Elderly and Late-Stage Elderly Patients―

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  • Higashino Masaaki
    Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Taniuchi Masataka
    Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Jin-nin Tsuyoshi
    Department of Otorhinolaryngology, Head and Neck Surgery, Rakuwakai Otowa Hospital
  • Omura Shuji
    Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Nishikawa Shuji
    Department of Otorhinolaryngology, Osaka-fu Saiseikai Suita Hospital
  • Aihara Teruhito
    Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Terada Tetsuya
    Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University
  • Kawata Ryo
    Department of Otorhinolaryngology, Head and Neck Surgery, Osaka Medical and Pharmaceutical University

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Other Title
  • 喉頭癌症例の世代別検討―壮年者, 前期高齢者, 後期高齢者の比較―
  • コウトウ ガン ショウレイ ノ セダイ ベツ ケントウ : ソウネンシャ,ゼンキ コウレイシャ,コウキ コウレイシャ ノ ヒカク

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Abstract

<p>　To compare the clinical features and treatments of laryngeal cancer patients by age group, We analyzed the data of 400 patients of laryngeal cancer who received the initial treatment at the Department of Otorhinolaryngology and Head and Neck Surgery, Osaka Medical College, from September 1999 to December 2017. We defined patients under 64 years of age as middle-aged patients, patients between 65 and 74 years of age as early-stage elderly patients, and patients over 75 years of age as late-stage elderly patients. The clinical features (disease stage, treatment, and outcome) were compared among the three age groups. In addition, data of the 200 cases seen in the first half of the study period were compared with those of the 200 cases seen in the latter half of the study period. There was no differences among the age groups in the stage distribution of glottic cancer, whereas in the cases of supraglottic cancer, the number of N+ cases was significantly higher in elderly patients as compared to the middle-aged patients. In both cases of glottic cancer and supraglottic cancer, there number of cases that received RT alone was higher in the late elderly patients as compared to the other age groups. There were no differences in the treatment outcomes among the age groups. The incidence of BSC was significantly higher in the early-stage and late-stage elderly patients, and higher in women than in men. In the 200 patients seen in the latter half of the study period, the average age was 3.1 years higher than that in the 200 patients seen in the first half of the study period. In regard to the treatment plan, in the middle-aged patients, total laryngectomy tended to shift to CDDPRT, and in the elderly patients, RT alone was the most frequently adopted treatment and the frequency of total laryngectomy was lower. However, the 200 patients seen in the first half and second half of the study period had similar survival curves. The average age of patients with laryngeal cancer has increased, and treatment has shifted to laryngeal preservation in all patients of all age groups. However, there has been no change in the disease-specific survival rate. The health status of elderly cancer patients varies, and it is necessary to take into account not only the stage of the disease, but also the general condition of the patient when selecting the appropriate treatment plan, including best supportive care.</p>

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