The Rheology of the Dynamic 3D Genome Organization

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  • 3次元ゲノムDNA動態のレオロジー特性
  • 3ジゲン ゲノム DNA ドウタイ ノ レオロジー トクセイ

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<p>Chromatin fibers, as the substance of the genome, are biopolymers packed inside the cell nucleus. High-throughput chromosome conformation capture (Hi-C) techniques have revealed the 3D genome organization for over a decade. Meanwhile, live-cell imaging experiments have shown the dynamic nature of chromatin. To bridge the gap between genome 3D structure and dynamics, we have developed a computational method for deciphering Hi-C data by polymer modeling. Here we provide a way to uncover the rheological properties of the dynamic 3D genome organization.</p>


  • Seibutsu Butsuri

    Seibutsu Butsuri 61 (5), 293-297, 2021

    The Biophysical Society of Japan General Incorporated Association


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