Maternal immune activation related to neurodevelopmental disorder‐like phenotype in mouse models

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  • Murakami Yuki
    Department of Hygiene and Public Health, Kansai Medical University
  • Imamura Yukio
    Organization for Research Initiatives and Development, Doshisha University Department of Traumatology and Acute Critical Medicine, Osaka University Graduate School of Medicine
  • Sakai Daisuke
    Department of Biology, Kanazawa Medical University
  • Konishi Yukuo
    Center for Baby Science, Doshisha University Healthcare and Medical Data Multi‐level Integration Platform Group, RIKEN Medical Sciences Innovation Hub Program

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  • 妊娠期の母胎炎症によって引き起こされる神経発達障害様モデル

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Abstract

Maternal stress, inflammation, and nutriture during pregnancy are correlated with a higher prevalence of neurodevelopmental disorders, such as autism spectrum disorder (ASD) , attention‐deficit/hyperactivity disorder, and intellectual disability. In the widely used maternal immune activation (MIA) rodent model, the pathology of ASD has been studied. Administration of the viral mimetic, toll‐like receptor (TLR) ligands, such as lipopolysaccharide or polyinosinic‐polycytidylic acid[poly (I : C) ], is commonly used as experimental tools to study neuronal and dysfunctions in ASD. However, a lot of evidence from investigations suggests that these TLR ligands can vary in terms of their immunogenicity in rodent. Here, we will introduce new research findings of the MIA‐induced ASD pathogenesis as well as the problems inducing inflammation by poly (I : C) administration. In addition, we will explain about the usability for a mouse MIA model by gene transfer system continuously expressing proinflammatory cytokine.

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