The composition of the human fecal microbiota might be significantly associated with fecal SCFA levels under hyperbaric conditions

DOI Web Site PubMed 参考文献20件 オープンアクセス
  • OYA Morihiko
    Research Division, Maritime Self-Defense Force Undersea Medical Center, Tauraminatocho, Yokosuka 237-0071, Japan
  • TOKUNAGA Tetsuji
    Clinical Division, Japan Self-Defense Force Yokosuka Hospital, Tauraminatocho, Yokosuka 237-0071, Japan
  • TADANO Yutaka
    Research Division, Maritime Self-Defense Force Undersea Medical Center, Tauraminatocho, Yokosuka 237-0071, Japan
  • OGAWA Hitoshi
    Research Division, Maritime Self-Defense Force Undersea Medical Center, Tauraminatocho, Yokosuka 237-0071, Japan
  • FUJII Shigenori
    Research Division, Maritime Self-Defense Force Undersea Medical Center, Tauraminatocho, Yokosuka 237-0071, Japan
  • MURAKAMI Wakana
    Research Division, Maritime Self-Defense Force Undersea Medical Center, Tauraminatocho, Yokosuka 237-0071, Japan
  • TAMAI Kenji
    Research Division, Maritime Self-Defense Force Undersea Medical Center, Tauraminatocho, Yokosuka 237-0071, Japan
  • IKOMI Fumitaka
    Research Division, Maritime Self-Defense Force Undersea Medical Center, Tauraminatocho, Yokosuka 237-0071, Japan National Defense Medical College Research Institute, 3-2 Namiki, Tokorozawa 359-8513, Japan
  • MORIMOTO Yuji
    Department of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan

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<p>The fecal microbiota and short-chain fatty acids (SCFAs) play important roles in the human body. This study examined how hyperbaric conditions affect the fecal microbiota and fecal SCFAs. Fecal samples were obtained from 12 divers at three points during deep-diving training (before the diving training, at 2.1 MPa, and after decompression). At 2.1 MPa, the changes in the frequency of Clostridium cluster IV and fecal iso-valerate levels were positively correlated, and the changes in the frequencies of Bacteroides and Clostridium subcluster XIVa were inversely correlated. After decompression, positive correlations were detected between the changes in the frequency of Bifidobacterium and fecal n-valerate levels and between the changes in the fecal levels of iso-butyrate and iso-valerate. On the other hand, inverse correlations were detected between the changes in the frequency of Clostridium cluster IX and fecal iso-butyrate levels, between the changes in the frequency of Clostridium cluster IX and fecal iso-valerate levels, and between the changes in the frequencies of Bacteroides and Clostridium cluster IV plus subcluster XIVa. During the study period, the changes in fecal iso-butyrate and iso-valerate levels were positively correlated, and inverse correlations were seen between the changes in the frequency of Clostridium cluster IV and fecal propionate levels and between the changes in the frequencies of Prevotella and Clostridium subcluster XIVa. These findings suggest that hyperbaric conditions affect the fecal microbiota and fecal SCFA levels and that intestinal conditions reversibly deteriorate under hyperbaric conditions.</p>

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