Paroxysmal Sympathetic Hyperactivity after Traumatic Brain Injury Experienced in Yamaguchi University

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  • 頭部外傷例におけるParoxysmal sympathetic hyperactivityの実態－山口大学脳神経外科の経験－
  • トウブ ガイショウ レイ ニオケル Paroxysmal sympathetic hyperactivity ノ ジッタイ : ヤマグチ ダイガク ノウ シンケイ ゲカ ノ ケイケン

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Abstract

<p>［Background and purpose］</p><p>Paroxysmal sympathetic hyperactivity（PSH）is a syndrome characterized by paroxysmal hyper-activation of sympathetic system which can manifest as tachycardia, high blood pressure, hyperventilation, hyperthermia, perspiration, and excessive muscle rigidity. In this study, we examined the actual state of the PSH following traumatic brain injury（TBI）as there were few reports of PSH associated with TBI.</p><p>［Clinical cases and method］</p><p>Ninety-seven patients with TBI were included</p><p>in this study. PSH was diagnosed according to the criteria reported by Baguley et al. In order to verify factors for developing PSH, and factors influencing outcome three months after injury,</p><p>we analyzed epidemiologic, physiological and biochemical data, and images of computed tomography scan.</p><p>［Results and interpretation］</p><p>Eleven patients were identified as having PSH, and incidence was 11.3%. PSH was significantly frequent in young, severe patients, and in those with focal injury. Multivariate analysis clarified that severity of TBI, PSH, and diffuse injury significantly and independently influenced poor prognosis after injury. The results suggest that</p><p>we may expect better outcomes if we find and treat PSH in the early stage following injury even in serious TBI cases.</p>

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