In vitro reconstruction of ligament-like tissue using decellularized membrane
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- Kimura Tsuyoshi
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
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- Suzuki Mika
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
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- Hashimoto Yoshihide
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
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- Takahashi Hironobu
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan
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- Shimizu Tatsuya
- Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, Tokyo, Japan
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- Nakamura Naoko
- Department of Bioscience and Engineering, College of Systems Engineering and Science Shibaura Institute of Technology, Saitama, Japan
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- Kishida Akio
- Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
Bibliographic Information
- Other Title
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- 靭帯再生を目指した脱細胞化膜状組織によるin vitro組織再構築
Abstract
<p>Recently, a decellularized tissue, which is extracellular matrix assembly, have been focused as one of candidate biomaterials. Recently, decellularized tendon and ligament have been tried as alternative tendon and ligament for tissue regeneration. However, it is difficult to recellularize inside of them. So, in this study, we proposed a method that decellularized membrane was recellularized and fabricated for in vitro reconstruction of ligament-like tissue having living cells. The decellularized pericardiums were prepared by two decellularized methods. Cells such as fibroblast, myoblast, mesenchymal stem cell, were adhered and cultivated on the decellularized pericardiums. The ligament-like tissue was reconstructed by rolling of the recellularized pericardiums with keeping the cellular adhesion in the inside. These results suggest that the ligament-like tissue could be reconstructed by using the recellularized pericardium.</p>
Journal
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- Transactions of Japanese Society for Medical and Biological Engineering
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Transactions of Japanese Society for Medical and Biological Engineering Annual59 (Abstract), 469-469, 2021
Japanese Society for Medical and Biological Engineering
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Details 詳細情報について
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- CRID
- 1390008290063886592
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- NII Article ID
- 130008105384
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- ISSN
- 18814379
- 1347443X
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed