Effects of acupuncture on oxidative stress level and antioxidant capacity in atopic dermatitis

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  • HAYASHI Yuri
    Morinomiya University of Medical Sciences Department of Acupuncture

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  • アトピー性皮膚炎の酸化ストレス度と抗酸化力に対する鍼治療の影響
  • アトピーセイ ヒフエン ノ サンカ ストレスド ト コウサンカリョク ニ タイスル シンチリョウ ノ エイキョウ

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Abstract

[Objective] The effects of acupuncture on oxidative stress level and antioxidant capacity have been reported in basic studies of acupuncture and moxibustion. However, to date, no studies have evaluated its effects in atopic dermatitis using oxidative stress levels and antioxidant capacity. Therefore, in Study 1, we compared the oxidative stress level and antioxidant capacity between healthy adults and patients with atopic dermatitis. In Study 2, we investigated the effects of acupuncture on atopic dermatitis using oxidative stress level and antioxidant capacity as indices. [Materials and Methods] Consent was obtained from five patients with atopic dermatitis and five healthy adults who were students at the Morinomiya University of Medical Sciences. Study 1 compared the oxidative stress level and antioxidant capacity between the patients with atopic dermatitis and the healthy adults. Study 2 investigated the effects of acupuncture with an extended reversal design (ABABA) with A as the untreated period and B as the acupuncture treatment period, each taking place for 10 weeks. For the evaluation, serum was used to measure the oxidative stress level (d-ROMs) and antioxidant power (BAP/OXY-absorbent). In addition, the evaluation measured the daily moisture content of the skin and the degree of itching. Acupuncture was performed with 0.16 × 40 mm disposable needles using needle placement therapy (10 minutes) at the bilateral chi ze (LU5), san yin jiao (SP6), and zu san li (ST36) points as well as two auxiliary points. [Results] Compared with the healthy adults, the patients with atopic dermatitis had increased oxidative stress levels to a "borderline level" and insufficient antioxidant capacity. Performing acupuncture in patients with atopic dermatitis significantly decreased and normalized the oxidative stress level. In contrast, the antioxidant capacity increased during both the acupuncture treatment period and the untreated period. No changes in skin moisture content or degree of itching were observed. [Discussion and Conclusion] Patients with atopic dermatitis had an increased oxidative stress level and insufficient antioxidant capacity. With repeated acupuncture, the oxidative stress level normalized. However, non-acupuncture factors may have affected antioxidant capacity, and the effects of acupuncture alone could not be verified. Since skin moisture content did not change with acupuncture, the degree of itching was not alleviated.

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