Treatment outcomes of acoustic neuromas with stereotactic radiotherapy (SRT)

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  • 定位的放射線治療（SRT）による聴神経腫瘍の治療成績

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    Outcomes of 20 acoustic neuromas in 19 patients, treated with stereotactic radiotherapy (SRT) mainly using a schedule with a total dose of 30 Gy in 3 fractions in 3 days, were estimated. Using MR images, mean tumor diameter (MD) was serially calculated. A status with an increment of MD above 2 mm and one with an additional neurological deficit related to tumor growth were regarded as clinically uncontrollable. Three-­ and 5-year actuarial clinical tumor control rate (CTCR) was 75% (12/16) and 61% (8/13), respectively. One patient developed slight impairment of trigeminal nerve as late sequela. Tumor control was better in smaller, MD being below median, or solid-type tumors. Five-year CTCR was 100% (7/7) and 89% (8/9), respectively. Many of them were gradually shrinking after SRT. On the other hand, tumor control was worse in larger, MD being above median, or cystic-type tumors. Five-year CTCR was 17% (1/6) and 0% (0/4), respectively. Many of them showed no regression or regrowth after temporal shrinkage following SRT. Salvage surgery was necessary only in 2 out of 19. SRT, using our schedule, is regarded safe in view of neurotoxicity. However, there appears some question regarding long-term tumor control in larger or cystic-type ones.

Journal

  • Hirosaki Medical Journal

    Hirosaki Medical Journal 55 (1), 7-17, 2003

    Hirosaki University Graduate School of Medicine,Hirosaki Medical Society

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