Role of activated eosinophils on Eosinophilic chronic rhinosinusitis

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  • Yun Yasutaka
    Department of Otorhinolaryngology, Head and Neck surgery, Kansai medical university
  • Kanda Akira
    Department of Otorhinolaryngology, Head and Neck surgery, Kansai medical university Department of Allergy center, Kansai Medical University
  • Kobayashi Yoshiki
    Department of Otorhinolaryngology, Head and Neck surgery, Kansai medical university Department of Allergy center, Kansai Medical University
  • Bui Van Dan
    Department of Otorhinolaryngology, Head and Neck surgery, Kansai medical university
  • Suzuki Kensuke
    Department of Otorhinolaryngology, Head and Neck surgery, Kansai medical university
  • Mitani Akitoshi
    Department of Otorhinolaryngology, Head and Neck surgery, Kansai medical university
  • Asako Mikiya
    Department of Otorhinolaryngology, Head and Neck surgery, Kansai medical university Department of Allergy center, Kansai Medical University
  • Iwai Hiroshi
    Department of Otorhinolaryngology, Head and Neck surgery, Kansai medical university

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Other Title
  • 好酸球性副鼻腔炎における活性化好酸球の役割
  • コウサンキュウセイ フクビクウエン ニ オケル カッセイカ コウサンキュウ ノ ヤクワリ

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<p>Eosinophilic chronic rhinosinusitis (ECRS) is an upper and lower airways eosinophilic airway inflammation that is frequently associated with asthma. Infiltrating the inflammatory region, tissue eosinophils are activated and play an important role in pathogenesis. Although CD69 is known as a marker of eosinophil activation, the functional role of CD69 has not been well understood. Therefore, we isolated eosinophils from the tissues of patients with ECRS to investigate the correlation between eosinophil activation and CD69 expression and its functional role. The results showed that CD69 was highly expressed in tissue eosinophils compared to eosinophils from peripheral blood, and that the expression level of CD69 correlated with the severity of symptoms. Furthermore, we found that CD69 stimulated the release of EPX (Eosinophilic Peroxidase). Thus, CD69 is expected to be a new target for therapeutic strategies against ECRS.</p>

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