Inhibition of tumor-associated antigens secreted from cancer cell lines by Taimatsu fermented rice germ solution containing inositol hexaphosphate (IP6)

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本研究では、我々が開発したIP6含有たいまつ米胚芽発酵液(T-IP6)の癌細胞株(MKN-45およびHepG2)から分泌される腫瘍関連抗原(CEAまたはPIVKA-II)に対する影響を化学発光および電気化学発光酵素免疫測定法で解析した。その結果、T-IP6で培養したMKN-45およびHepG2細胞から分泌されるCEAまたはPIVKA-IIは、細胞の形態変化を伴いながら有意に抑制された(P<0.01)。また、T-IP6によるCEAまたはPIVKA-IIの抑制作用は濃度依存性であった(P<0.05)。以上の結果から、T-IP6にはヒトの癌細胞を正常化させる作用があることがわかった。

Inositol hexaphosphate (IP6), a naturally polyphosphorylated carbohydrate, has been reported to have significant anticancer activity against numerous tumors, such as colon, prostate, breast, liver and rhabdomyosarcomas. Recently, we established a new IP6-containing solution, designated as T-IP6, produced by Taimatsu fermented rice germ. In this study, we examined the inhibitory effects of tumor-associated antigens secreted from a gastric cancer cell line (MKN-45) and a hepatocellular carcinoma cell line (HepG2) exposed to T-IP6. The tumor-associated antigens, such ascarcinoembryonic antigen (CEA) and protein induced by vitamin K absence or antagonists-II (PIVKAII), secreted from these cancer cell lines cultured with T-IP6 were significantly inhibited (P<0.01), compared with those in control cells (cultured without T-IP6) at 72 hrs, and this inhibition was accompanied by morphological changes, respectively. In addition, T-IP6 inhibited CEA and PIVKA-II in a dose-dependent manner. These findings suggest that T-IP6 has an immunoinhibitory and normalization effect in human cancer cells.

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