Association of paraoxonase 1 gene polymorphism with Intima-Media Thickness (IMT) of the carotid arteries in japanese type 2 diabetic patients
この論文をさがす
説明
Purpose: We investigated the association between paraoxonase 1 (PON1)-192 genotypes and intimamedia thickness (IMT) of carotid arteries in diabetic patients. Methods: One hundred and fifty-five Japanese type 2 diabetic patients aged from 40 to 79 years were enrolled in this study. Genotypes of the patients were determined using the PCR-RFLP method. The IMT of carotid arteries of the subjects was measured by ultrasound imaging. Results: The PON1 genotypes frequencies were as follows: 18QQ (0.116), 70QR (0.452) and 67RR (0.432). IMT values of the RR group were significantly greater (1.08±0.41 mm, n=67) than those of the Q group, which consisted of patients carrying one or two Q alleles (0.95±0.27 mm, n=88, P=0.023). There were no significant difference in the clinical characteristics between the two groups. Conclusion: The results indicate that the PON1-192RR genotype is associated with intima media thickening of the carotid arteries in diabetic patients.
P(論文)
40019736749
原著論文
application/pdf
ORIGINAL ARTICLE
収録刊行物
-
- 麻布大学雑誌
-
麻布大学雑誌 24 31-35, 2013-01-31
麻布大学
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390009224622080512
-
- NII論文ID
- 120005406610
-
- NII書誌ID
- AA11561468
-
- NDL書誌ID
- 024748425
-
- ISSN
- 13465880
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- IRDB
- NDL
- CiNii Articles