Histopathological Study on the Prognosis of pT2 Gastric Cancer

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The prognosis of gastric cancer was investigated in relation to histopathological grading and amount of interstitial connective tissue in 42 patients with gastric cancer pervading the muscularis propria but without invading the serosa (pT2 gastric cancer). The 5- and 10-year survival rates of patients with this type of gastric cancer were 76.3% and 47.3%, respectively. On examining the relation between the prognosis and the histopathological grading, the 5-year survival rate was 82.4% in cases with low degree of differentiation and 66.5% in cases with high and medium degrees of differentiation. No significant statistical difference was seen. The prognosis in relation to the amount of interstitial connective tissue a 5-year survival rate of 91.3% in cases with rich interstitia (scirrhous type), 76.5% in those with intermediate type, and 43.3% in cases with medullary type, thus revealing a favorable prognosis in the first type and a poor one in the last type (p≒0.03). The prognosis was extremely poor in cases of meduallary type with low degree of differentiation; these cases had a high rate of mortality from recurrence in the liver and a tendency toward early recurrence. In contrast, a favorable prognosis with a high 5-year survival rate was noted in cases with rich interstitia.

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