Investigation of a family with the Ala18Val hetero variants of the PPARγ2 in Japanese Black cattle (Tajima strain), Japanese Brown cattle (Kouchi strain), and Mishima cattle

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  • 但馬系黒毛和種, 高知系褐毛和種および見島牛における PPARγ2 変異個体の家系調査
  • タジマケイ クロゲワシュ コウチケイカツモウ ワシュ オヨビ ミシマギュウ ニ オケル PPAR ガンマ 2 ヘンイ コタイ ノ カケイ チョウサ

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Abstract

PPARγ2 plays an important role in adipocyte differentiation. The Pro12Ala substitution of PPARγ2 is associated with obesity in human, and the Ala18Val seems to be associated with carcass traits of Japanese Black cattle. Here, we investigate the Ala18Val hetero variants of PPARγ2 (Ala/Val variant) in 52 Japanese Black cattle (Tajima strain), 82 Japanese Brown cattle (Kouchi strain), and 14 Mishima cattle, using sires and their closely related offspring. In the Japanese Black cattle (Tajima strain), we found a family derived from one sire of the Ala/Val variant. The family contained 52 sires, which were kept in 21 prefectures throughout Japan. We confirmed that this family contained 4 sires that were Ala/Val variants, and these 4 sires had produced about 13,000 offspring. As for the remaining 48 sires, about half were estimated to be Ala/Val variants. On the other hand, we found no Ala/Val variants in the Japanese Brown cattle (Kouchi strain) or in the Mishima cattle.

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