乳癌細胞でのカリウムチャネルに関する電気生理学的検討

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タイトル別名
  • ニュウガン サイボウ デ ノ カリウムチャネル ニ カンスル デンキ セイリガクテキ ケントウ
  • An electrophysiological study of breast cancer cell HCC1937

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Potassium channels are considered as key molecules in the progression of several cancer types. Human ether a go-go (hEAG) potassium channels have been reported to possess oncogenic properties and to regulate the cell cycle. The present study was designed to elucidate the physiological manifestation of the potassium channel in one of breast cancer cell lines called HCC1937 by using the patch clamp technique. The outward currents were elicited by the depolarizing clamp pulses in MFC-7. On the other hand, the similar outward currents were not elicited in HCC1937 cells. The present results revealed that the voltage-dependent potassium channels seemed not to be abundantly populated in HCC1937 compared with MFC-7. Therefore, it can be considered that the degree of the potassium channel contribution to proliferation and/or the type of potassium channels associated with proliferation varies among different cell lines of breast cancer.

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