A Case of Poisoning in a Man who Drank a Nutrition Supplement Containing Methomyl, A Carbamate Pesticide

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  • Kudo Keiko
    Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University
  • Hida Yoshihiro
    Forensic Science Laboratory , Fukuoka Prefectural Police Headquarters
  • Zaitsu Akinori
    Department of Emergency Service, Kyushu University Hospital
  • Inoue Hiromasa
    Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University
  • Tsuji Akiko
    Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University
  • Ishida Tomomi
    Forensic Science Laboratory , Fukuoka Prefectural Police Headquarters | Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University
  • Ikeda Noriaki
    Department of Forensic Pathology and Sciences, Graduate School of Medical Sciences, Kyushu University

Bibliographic Information

Other Title
  • カーバメート系農薬メソミルが混入された栄養ドリンク剤の飲用による中毒の一例
  • Case Report: A Case of Poisoning in a Man who Drank a Nutrition Supplement Containing Methomyl, A Carbamate Pesticide

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Description

A 50-year-old man was admitted to the emergency room complaining oppression on his chest, sweating and vomiting. He had drunk a 30 ml volume nutrition supplement 60 minutes before. As myosis and decrease of serum choline esterase activity were observed on admission examination, poisoning was suspected and toxicological analyses were carried out on the heeltap of the drink. Drug screening by gas chromatography-mass spectrometry (GC/MS) revealed the presence of methomyl and the concentration of methomyl in the heeltap determined by liquid chromatography was 2.1 mg/ml. Methomyl concentrations in the serum and urine were determined after converting methomyl to its oxime form followed by derivatization and GC/MS. Methomyl concentration in the serum collected 6 hours after ingestion was 0.63 ,μg/ml, and that in the urine collected 7-20 hours after ingestion was 0.10 μg/ml. Based on these values and reported data, the amount of methomyl contaminated to the drink was considered to be a toxic dose.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 96 (7), 305-310, 2005-07-25

    Fukuoka Medical Association

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