Pseudoprogression Following Concurrent Temozolomide and Radiotherapy in a Patient with Glioblastoma : Findings on Functional Imaging Techniques

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  • Shirakawa Yuko
    Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Yoshiura Takashi
    Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Hiwatashi Akio
    Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Yamashita Koji
    Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Kamano Hironori
    Departments of Neurosurgery, Graduate School of Medical Sciences, Kyushu University | Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Shioyama Yoshiyuki
    Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Abe Kouichiro
    Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University
  • Amano Toshiyuki
    Departments of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
  • Nakamizo Akira
    Departments of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
  • Yoshimoto Koji
    Departments of Neurosurgery, Graduate School of Medical Sciences, Kyushu University
  • Honda Hiroyuki
    Departments of Neuropathology, Graduate School of Medical Sciences, Kyushu University
  • Torisu Rina
    Departments of Neuropathology, Graduate School of Medical Sciences, Kyushu University
  • Suzuki Satoshi
    Departments of Neuropathology, Graduate School of Medical Sciences, Kyushu University
  • Honda Hiroshi
    Departments of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University

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Other Title
  • 膠芽腫の化学放射線治療後にpseudoprogressionを生じた一例 : 機能画像での所見

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Abstract

Concurrent temozolomide (TMZ) and radiotherapy became the new standard of care for patients diagnosed with glioblastoma multiforme (GBM). Recently, there has been an increasing awareness of progressive and enhancing lesions on MR images immediately after treatment. These lesions may be a treatment effect, so-called pseudoprogression. We experienced one case pathologically and clinically diagnosed as pseudoprogression. The lesion showed a high apparent diffusion coefficient on diffusion-weighted imaging, low blood volume on perfusion imaging, and low uptake of 18F-fluorodeoxyglucose on positron emission tomography. The lesion was pathologically diagnosed as pseudoprogression after additional surgical resection.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 101 (12), 257-264, 2010-12-25

    Fukuoka Medical Association

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