The Effect of Maternal Exposure to Dioxin on Fetal Steroidogenesis in the Steroidogenic Organs
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- Takeda Tomoki
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Taura Junki
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Fujii Misaki
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Koga Takayuki
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Ishii Yuji
- Graduate School of Pharmaceutical Sciences, Kyushu University
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- Yamada Hideyuki
- Graduate School of Pharmaceutical Sciences, Kyushu University
Bibliographic Information
- Other Title
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- ダイオキシン母体曝露が胎児ステロイド産生臓器の性ステロイドホルモン合成系に及ぼす影響
- ダイオキシン ボタイ バクロ ガ タイジ ステロイド サンセイ ゾウキ ノ セイ ステロイドホルモン ゴウセイケイ ニ オヨボス エイキョウ
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Abstract
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposed to pregnant or lactational mother impairs the reproduction and development of the pups. The defect is a serious problem, because it is caused by TCDD at much lower doses than that needed for acute toxicity in the mother. However, the toxic mechanism underlying the defect remains to be obscure. We have previously revealed that maternal exposure to TCDD (1 μg/kg) causes a reduction in luteinizing hormone in the fetal pituitary, leading to the reduced expression of testicular steroidogenic proteins such as steroidogenic acute-regulatory protein (StAR) and cytochrome P450 (CYP) 17. In addition, we have provided evidence that such a reduction imprints defects in sexual behaviors at adulthood. In this study, we investigated TCDD effect on fetal steroidogenesis in the extra-gonadal tissues. Even when pregnant Wistar rats at gestational day (GD) 15 were orally treated with TCDD (0.25, 1 or 3 μg/kg), neither expression of StAR nor CYP17 mRNA was affected in the adrenal gland, placenta and hypothalamus of male fetuses (GD20). However, TCDD induced placental StAR (3 μg/kg) and adrenal CYP17 mRNAs (0.25 μg/kg) in female fetuses. Therefore, our study suggests that while TCDD gives damage to male fetal steroidogenesis in a testis-specific manner, the dioxin enhances the steroidogenesis of the fetal adrenal gland and placenta in females. Thus, the mechanism whereby TCDD exerts its endocrine-disrupting properties is considered to differ, at least partially, between male and female fetuses.
Journal
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- 福岡醫學雜誌
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福岡醫學雜誌 102 (4), 159-166, 2011-04-25
Fukuoka Medical Association
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Keywords
Details 詳細情報について
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- CRID
- 1390009224763765120
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- NII Article ID
- 40018966704
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- NII Book ID
- AN00215478
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- DOI
- 10.15017/19738
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- HANDLE
- 2324/19738
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- NDL BIB ID
- 11215090
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- ISSN
- 0016254X
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- PubMed
- 21706896
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- Text Lang
- ja
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- Data Source
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- JaLC
- IRDB
- NDL
- PubMed
- CiNii Articles
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- Abstract License Flag
- Allowed