Uterine Leiomyosarcoma : An Aggressive and Challenging Malignant Tumor

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  • Sonoda Kenzo
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University

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  • 子宮平滑筋肉腫の分子生物学的特性を踏まえた新たな治療戦略の構築

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Abstract

Uterine leiomyosarcoma is a highly aggressive and lethal disease. Even after comprehensive staging or cytoreductive surgery, followed by multidisciplinary therapies, many patients relapse and finally die of this disease. These poor outcomes associated with uterine leiomyosarcoma can be explained, in part, by the rarity, unknown etiology, and highly divergent genetic aberrations of the disease. Significant advances in molecular biology and genetic research have allowed better identification of the molecular signatures of leiomyosarcoma and may help to establish an optimal treatment strategy for this disease. The clinical features, treatments, genetic profiles, and omics-based studies of specific biomarkers for leiomyosarcoma are reviewed in this article.

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 108 (2), 24-41, 2017-02-25

    Fukuoka Medical Association

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