Expression of p16^<INK4a> in Squamous Cell Carcinoma Arising from Porokeratosis

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  • Furue Masutaka
    Department of anatomic pathology, graduate school of medical sciences, Kyushu University | Division of Skin Surface Sensing, Department of Dermatology, Kyushu University | Research and Clinical Center for Yusho and Dioxin, Kyushu University
  • Sato Seisho
    Department of Dermatology, Kyushu University
  • Tsukamoto Karin
    Department of Dermatology, Kyushu University
  • Nakamoto Sumire
    Department of Dermatology, Kyushu University
  • Hikichi Shiori
    Department of Dermatology, Kyushu University
  • Yokote Ginju
    Department of Dermatology, Kyushu University
  • Dugu Long
    Department of Dermatology, Kyushu University
  • Take Nobutoshi
    Department of Dermatology, Kyushu University

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Other Title
  • 汗孔角化症由来有棘細胞癌におけるp16^<INK4a>の発現

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Abstract

The expression of p16I^<INK4a> has been reported to induce cell cycle arrest and cellular senescence.We recently demonstrated that p16I^<INK4a> expression is an integral part of the pathogenesis of porokeratosis. In this study, we further examined the p16I^<INK4a> expression in squamous cell carcinoma (SCC) arising from disseminated porokeratosis. p16I^<INK4a>-expressing keratinocytes were detected in the porokeratotic epidermis and atypical keratinocytes in the SCC in situ developed from porokeratosis. The expression of p16INK4a was also detected in the invasive SCC cells ; however, it was eventually lost in the tumoral nests. These results suggest that the aberrant expression of p16I^<INK4a> in affected keratinocytes may be related to the pro-oncogenic nature of porokeratosis. Its expression may be lost by subsequent tumor progression

Journal

  • 福岡醫學雜誌

    福岡醫學雜誌 108 (6), 176-182, 2017-06-25

    Fukuoka Medical Association

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