自然免疫の異物識別機構への理解を促すTLRカードゲームの開発<数学・自然科学>

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Toll-like receptors (TLRs) are protein sensors located on immune cells, which function as pathogen recognition by the innate immune system. These TLRs form a homodimer or a heterodimer, which recognizes distinct pathogen-associated molecular patterns. The explanation of the TLRs and their function have been introduced on Japanese biological textbooks for high school students since 2012. Here, I developed a card game, TLR Card Game, as an educational material for understanding the mechanism of the innate pathogen recognition. The TLR Card Game is for multiplayers who are surrounding a table where several pairs of a phagocytic cell board and a pathogen card are set. Each player has to present two TLR cards from his own hand in his turn, making a TLR dimer corresponding to a pathogen card presenting on the table. When a TLR card-pair is presented correctly, a player can get several points, and the player with highest points finally gets win. The TLR Card Game was carried out in an extracurricular class of a high school in Saitama City. The effectiveness of the game was assessed by open- and close-ended questionnaires for 30 students. All the students got interested in the TLR Card Game and its immunology. Some students, however, answered that the game and the immune mechanism were not much linked in their thought. The TLR Card Game is considered useful for students attracted towards immunology, but the instructions before use needed to be improved.

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