Effects of exercise intensity on salivary level of secretory immunoglobulin A in patients with chronic obstructive pulmonary disease

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  • 慢性閉塞性肺疾患患者における一過性運動負荷強度の違いが唾液中分泌型免疫グロブリンAに及ぼす影響
  • マンセイ ヘイソクセイ ハイ シッカン カンジャ ニ オケル イッカセイ ウンドウ フカ キョウド ノ チガイ ガ ダエキ チュウ ブンピツガタ メンエキ グロブリン A ニ オヨボス エイキョウ

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Abstract

The present study was designed to examine the effects of exercise intensity on local immunity of the upper respiratory tract. We measured salivary levels of secretory immunoglobulin A (SIgA) in five outpatients with chronic obstructive pulmonary disease (COPD). Maximum walking speed for each subject was determined by incremental shuttle walking test (ISWT). Exercise was 20 min walking on a treadmill at speeds of 40% or 80% of ISWT (40% or 80% ISWT). Saliva samples were collected before and after exercise. Salivary SIgA concentrations were measured by enzyme-linked immunosorbent assay and secretion rates (μg/min) were calculated by multiplying the salivary SIgA concentration by saliva flow rate (ml/min) for each subject. After 40% ISWT, the salivary SIgA secretion rate of three patients decreased but that of the other two increased. After 80% ISWT, the salivary SIgA secretion rate of four patients decreased while that of the remaining one increased. It was suggested that in addition to the decline in local immunity after high intensity exercise like that seen in a normal healthy subject, the local immunity of the upper respiratory tract for COPD patients deceased after even low intensity exercise.

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