The Expression of Mitsugumin 53 in SHRSP・Z-Leprfa/NDmcr

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  • SHRSP・Z-Leprfa/NDmcr ラット におけるインスリン抵抗性関与因子Mitsugumin 53 発現の検討
  • SHRSP ・ Z-Lepr[fa]/NDmcr ラット ニ オケル インスリン テイコウセイ : カンヨ インシ Mitsugumin 53 ハツゲン ノ ケントウ

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Abstract

We observed changes in body weight and fat tissue organs in SHRSP・Z-Leprfa/NDmcr（SPZF） rats at 12 and 18 weeks of age. Plasma glucose and insulin concentrations were significantly higher in SPZF than in WKY rats. Homeostasis model assessment-insulin resistance in SPZF was significantly higher than in WKY rats. MG53 protein expression in skeletal muscles from SPZF was significantly higher than that in skeletal muscles from WKY rats. These findings suggest that SPZF shows insulin resistance. MG53 may affect the development of insulin resistance in SPZF.

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