Spontaneously Hypertensive Rat, Stroke-prone Spontaneously Hypertensive Rat 及びWistar Kyoto Rat の24時間血圧概日リズムの基礎的検討

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  • Twenty-four-hour blood pressure in Spontaneously Hypertensive rats, Stroke-prone Spontaneously Hypertensive rats, and Wistar Kyoto rats
  • Spontaneously Hypertensive Rat, Stroke-prone Spontaneously Hypertensive Rat オヨビ Wistar Kyoto Rat ノ 24ジカン ケツアツ ガイジツ リズム ノ キソテキ ケントウ

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Twenty-four-hour ambulatory blood pressure monitoring has focused on the incidence of hypertension-related end organ damage. This study analyzed 24-hour blood pressure in normotensive Wistar Kyoto rats（WKY）, spontaneously hypertensive rats（ SHR）, and stroke-prone SHR（ SHRSP）, which are used as a model of hypertension. Each rat at 12 weeks of age was used for 24-hour blood pressure monitoring for 7 days. This ambulatory blood pressure monitoring was conducted using a telemetry system. Twenty -four-hour systolic and diastolic blood pressures in SHRSP（ n=5） were significantly higher than in SHR（ n=5） and WKY（ n=5）, but the heart rate did not change among these strains. SHRSP showed the non-dipper phenomenon for 2 days. From these results, the circadian rhythm in 24-hour ambulatory blood pressure of SHRSP was different from those in SHR and WKY, possibly due to marked hypertension.

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