(E)-N-(3,4-dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl) diazenyl)Benzenesulfonamide; A New Synthetic Anti-Herpetic Agent for HSV-1

DOI 機関リポジトリ (HANDLE) オープンアクセス
  • Kumar Ashish
    Department of Applied Science & Humanities, G.L. Bajaj Institute of Technology & Management
  • Brij Kishore Tiwari
    Department of Applied Science & Humanities, G.L. Bajaj Institute of Technology & Management
  • Mishra Mamta
    Department of Applied Science & Humanities, G.L. Bajaj Institute of Technology & Management
  • Kumar Navneet
    Department of Applied Science & Humanities, Inderprastha Engineering College

説明

Abstract:(E)-N-(3,4-dimethylisoxazol-5-yl)-4-((4-hydroxy-2-oxo-2H-chromen-3-yl)diazenyl)benzene sulfonamide (HDF) was prepared by condensation of 4-hydroxy coumarin and 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzene sulfonamide (sulphafurazole). The structure of synthesized compound was established using IR, 1H and 13C-NMR spectral analysis. On evaluation of in-vitro anti-herpetic activity of this compound against HSV-1, compound was found able to inhibit viral replication at late stages of infection by inhibiting the replication of HSV-1. This anti herpetic nature of HDF was evidenced by the reduction of specific gene productsβ-(ICP-6) and γ-(ICP-5 and gB) groups in western blotting.

収録刊行物

  • Evergreen

    Evergreen 8 (2), 351-357, 2021-06

    九州大学グリーンテクノロジー研究教育センター

キーワード

詳細情報 詳細情報について

  • CRID
    1390009225530952448
  • NII論文ID
    120007099188
  • DOI
    10.5109/4480717
  • ISSN
    24325953
    21890420
  • HANDLE
    2324/4480717
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • IRDB
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用可

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