感覚評価を用いたベンゾピレン投与ラットに対するケイヒの効果検討

DOI 機関リポジトリ (HANDLE) Web Site オープンアクセス
  • 申 敏哲
    熊本保健科学大学保健科学部リハビリテーション学科
  • 行平 崇
    熊本保健科学大学保健科学部リハビリテーション学科 帝京大学福岡医療技術学部理学療法学科
  • 小牧 龍二
    熊本保健科学大学保健科学部リハビリテーション学科 リハビリテーションセンター熊本回生会病院
  • 福永 貴之
    九州大学大学院薬学研究院分子衛生薬学分野 くまもと南部広域病院
  • 田中 哲子
    熊本保健科学大学保健科学部リハビリテーション学科
  • 土井 篤
    熊本保健科学大学保健科学部リハビリテーション学科
  • 吉村 恵
    医療法人社団温故会直方中村病院

書誌事項

タイトル別名
  • Effect of Cinnamon on Benzo[a]pyrene-Treated Rats using Quantitative Threshold Evaluation
  • 感覚評価を用いたベンソピレン投与ラットに対するケイヒの効果検討
  • カンカク ヒョウカ オ モチイタ ベンソピレン トウヨ ラット ニ タイスル ケイヒ ノ コウカ ケントウ

この論文をさがす

説明

In this study, we investigated the effect of cinnamon on rats treated with benzo[a]pyrene. The investigations were performed using quantitative threshold evaluations with three different sensory stimuli at 5 Hz, 250 Hz, and 2,000 Hz, by measuring oxidative stress/antioxidants, and using Western blotting for components of the associated pathways. We found that no significant threshold change could be observed after a single dose of electrical stimulation frequencies of 5 Hz and 250 Hz during benzo[a]pyrene acute poisoning in rats. The electrical stimulation frequency of 2,000 Hz resulted in an increase in the sensory threshold of benzo [a]pyrene-treated rats. However, this increase in the threshold tended to be suppressed by the administration of cinnamon. A significant improvement in the oxidative stress state was observed among the cinnamon-treated rats compared with the benzo[a]pyrene-treated rats. The western blot analysis revealed that the decreased expression of myelin-associated glycoprotein (MAG) and the increased expression of cytochrome P450 (P450) 1A1 (CYP1A1) in the benzo [a]pyrene-treated rats were inhibited and increased upon cinnamon administration, respectively. However, there was no significant difference between the groups in terms of the expression of myelin basic protein (MBP). Administration of 3 mg/kg cinnamon, which was effective in benzo[a]pyrene single dose rats, slightly improved the sensory threshold, oxidative stress state, CYP1A1, MBP, and MAG protein expression in the rats exposed to benzo[a]pyrene for 2 weeks, but with no significant difference. These results indicate that the administration of benzo[a]pyrene may lead to paresthesia by causing demyelination due to its toxicity on Ab fibers that transmit tactile and pressure sensations. In addition, the administration of cinnamon may also improve paresthesia by suppressing AHR activation and oxidative stress. However, it has been suggested that the effective intake concentration and duration of exposure to cinnamon may differ depending on the duration of exposure to benzo[a]pyrene.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ