Analysis of Pressures at Which Ultrasonic Diagnostic Microbubbles Collapse

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  • Abe Takuya
    Department of Health Science, Field of Safety and Risk Management for Medical Technology, Niigata University of Health and Welfare Graduate School
  • Fujii Yutaka
    Department of Health Science, Field of Safety and Risk Management for Medical Technology, Niigata University of Health and Welfare Graduate School
  • Hanawa Haruo
    Department of Health and Sports, Niigata University of Health and Welfare, Faculty of Health Sciences
  • Iguchi Keita
    Department of Health Science, Field of Safety and Risk Management for Medical Technology, Niigata University of Health and Welfare Graduate School
  • Takahashi Kazuaki
    Department of Health Science, Field of Safety and Risk Management for Medical Technology, Niigata University of Health and Welfare Graduate School
  • Takahashi Yoshimitsu
    Department of Clinical Engineering and Medical Technology, Niigata University of Health and Welfare, Faculty of Medical Technology
  • Watanabe Hiroaki
    Department of Clinical Engineering and Medical Technology, Niigata University of Health and Welfare, Faculty of Medical Technology
  • Ikegami Kikuo
    Department of Health Science, Field of Safety and Risk Management for Medical Technology, Niigata University of Health and Welfare Graduate School
  • Kubono Katsuo
    Department of Health Science, Field of Safety and Risk Management for Medical Technology, Niigata University of Health and Welfare Graduate School
  • Nagahama Daisuke
    Department of Health Science, Field of Safety and Risk Management for Medical Technology, Niigata University of Health and Welfare Graduate School

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Other Title
  • 超音波診断用マイクロバブルの許容圧力の検討
  • チョウオンパ シンダンヨウ マイクロバブル ノ キョヨウ アツリョク ノ ケントウ

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<p>Purpose: It is known that the perflubutane microbubbles (PFBs) of Sonazoid®, a contrast medium used for the ultrasonic diagnosis of tumor lesions, disintegrate easily when pressure is applied. The purpose of this study was to quantitatively examine the pressure at which PFBs disintegrate and to evaluate the number and size of PFBs and their contrast effect to establish a standard when administering contrast media.</p><p>Subjects and Methods: Pressurization was performed by connecting a syringe containing Sonazoid®PFBs to a syringe pump, which was operated with a closed syringe port. A pressure sensor was attached to the syringe port to evaluate the changes in the properties and quantity of PFBs due to the differences in pressure. Furthermore, an original phantom was prepared, and the contrast effect of PFBs was examined after the pressurization.</p><p>Results and Discussion: The number of PFBs decreased with pressurization; it decreased by about 60% with pressures ≥900 mmHg. At 900–1,000 mmHg, PFBs that were ≥2–3 µm in size, which play an important role in the contrast effect, collapse, and a hypoechoic ultrasonic image was also displayed in the contrast medium administration part of the original phantom.</p><p>Conclusion: This study quantitatively examined the pressure at which PFBs can maintain the contrast effect. PFBs decreased when the pressure was ≥900 mmHg, and a pressure of 1,000 mmHg affected the contrast effect.</p>

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