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Efficacy and Safety of Condoliase Disc Administration as a New Treatment for Lumbar Disc Herniation
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- Inoue Masahiro
- Department of Orthopaedic Surgery, Eastern Chiba Medical Center
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- Sainoh Takeshi
- Department of Orthopaedic Surgery, Sainou Hospital
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- Kojima Atsushi
- Department of Orthopaedic Surgery, Funabashi Orthopaedic Hospital
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- Yamagata Masatsune
- Department of Orthopaedic Surgery, Chiba Rosai Hospital
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- Morinaga Tatsuo
- Department of Orthopaedic Surgery, Kashiwa Municipal Hospital
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- Mannoji Chikato
- Department of Orthopaedic Surgery, Japanese Red Cross Narita Hospital
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- Ataka Hiromi
- Department of Orthopaedic Surgery, Matsudo Orthopaedic Hospital
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- Yamashita Masaomi
- Department of Orthopaedic Surgery, Funabashi Central Hospital
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- Takahashi Hiroshi
- Department of Orthopaedic Surgery, University of Tsukuba
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- Saito Junya
- Department of Orthopaedic Surgery, Toho University of Sakura Hospital
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- Fujiyoshi Takayuki
- Department of Orthopaedic Surgery, Kimitsu Chou Hospital
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- Ishikawa Tetsuhiro
- Department of Orthopaedic Surgery, Sanmu Medical Center
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- Eguchi Yawara
- Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University
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- Kato Kei
- Department of Orthopaedic Surgery, Matsudo City General Hospital
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- Orita Sumihisa
- Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University
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- Inage Kazuhide
- Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University
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- Shiga Yasuhiro
- Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University
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- Norimoto Masaki
- Department of Orthopaedic Surgery, Toho University of Sakura Hospital
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- Umimura Tomotaka
- Department of Orthopaedic Surgery, Sanmu Medical Center
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- Shiko Yuki
- Biostatistics Section, Clinical Research Center, Chiba University Hospital
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- Kawasaki Yohei
- Biostatistics Section, Clinical Research Center, Chiba University Hospital
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- Aoki Yasuchika
- Department of Orthopaedic Surgery, Eastern Chiba Medical Center
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- Ohtori Seiji
- Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University
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Description
<p>Introduction: Condoliase is a newly approved drug that improves symptoms associated with lumbar disk herniation (LDH) by intradiscal administration. This study aimed to evaluate the mid-term outcomes of condoliase injection, examine the adverse events, including cases that required surgery after condoliase administration, and verify cases in which condoliase could be effective.</p><p>Methods: We enrolled patients with LDH who were treated conservatively for at least six weeks and received condoliase. We assessed the visual analog scale (VAS) score, Japanese Orthopaedic Association Back Pain Evaluation Questionnaire, Oswestry Disability Index, disk height, and disk degeneration for up to 6 months, and we examined the complications. Furthermore, a 50% or more improvement in leg pain VAS score was considered effective. Factors related to symptom improvement were investigated by determining whether lower limb pain improved in six months.</p><p>Results: In total, 84 patients were recruited (52 men, 32 women; mean age, 44.2 ± 17.1 [16-86 years]). The duration of illness was 6.7 ± 6.8 (1.5-30) months. All patient-based outcomes significantly improved at 4 weeks after the administration compared with pretreatment. The intervertebral disc height decreased significantly at four weeks after condoliase administration compared with that before administration. Progression of intervertebral disc degeneration occurred in 50% of the patients. Eleven patients underwent herniotomy due to poor treatment effects. Moreover, treatment in 77.4% of the patients was considered effective. A logistic regression analysis revealed that L5/S1 disk administration (p = 0.029; odds ratio, 5.94; 95% confidence interval, 1.20-29.45) were significantly associated with clinical effectiveness.</p><p>Conclusions: Condoliase disk administration improved pain and quality of life over time. Condoliase disk administration was more effective in L5/S1 intervertebral administration.</p>
Journal
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- Spine Surgery and Related Research
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Spine Surgery and Related Research 6 (1), 31-37, 2022-01-27
The Japanese Society for Spine Surgery and Related Research