A case of IgG4-related autoimmune hepatitis that was difficult to diagnosis
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- Ikeda Shinya
- Department of Gastroenterology, Enshu Hospital
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- Mori Taiki
- Department of Gastroenterology, Enshu Hospital
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- Takeuchi Yasuo
- Department of Gastroenterology, Enshu Hospital
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- Takagaki Kosuke
- Department of Gastroenterology, Enshu Hospital
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- Uemura Takashi
- Department of Pathology, Enshu Hospital
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- Shirai Naohito
- Department of Gastroenterology, Enshu Hospital
Bibliographic Information
- Other Title
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- 診断に苦慮したIgG4関連自己免疫性肝炎の1例
- シンダン ニ クリョ シタ IgG4 カンレン ジコ メンエキセイ カンエン ノ 1レイ
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Description
<p>An 80-year-old man presented to our hospital complaining of epigastric pain. His levels of hepatobiliary system enzymes were elevated. Computed tomography (CT) showed no obvious common bile duct stones but mild bile duct dilatation was present. He was admitted to the hospital for treatment of suspected cholangitis. Repeated endoscopic bile duct drainage did not improve the liver damage. Although serum immunoglobulin (Ig) G was mildly elevated, viral markers and autoantibodies were negative. Liver biopsy showed nonspecific, chronic active hepatitis but did not lead to a definitive diagnosis. Additional blood tests showed high IgG4 levels and IgG4 immunostaining of liver biopsy pathology showed IgG4-positive plasma cell infiltration in the portal. Based on the above, the patient was diagnosed with IgG4-related autoimmune hepatitis, and prednisolone (PSL) was started; the liver damage promptly improved. This case demonstrates that measurement of serum IgG4 and IgG4 immunostaining of liver tissue may be useful for the diagnosis of liver disorders of unknown origin.</p>
Journal
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- Kanzo
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Kanzo 63 (2), 43-50, 2022-02-01
The Japan Society of Hepatology
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Details 詳細情報について
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- CRID
- 1390009640069575168
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- NII Article ID
- 130008158700
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- NII Book ID
- AN00047770
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- ISSN
- 18813593
- 04514203
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- NDL BIB ID
- 031964936
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed