Solid-in-Oil Nanodispersion Technique for Transdermal Drug Delivery System of Biopharmaceutical Molecules

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  • TAHARA Yoshiro
    Department of Chemical Engineering and Materials Science, Doshisha University
  • GOTO Masahiro
    Department of Applied Chemistry, Graduate School of Engineering, Kyushu University

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Other Title
  • Solid-in-Oil（S/O）技術とバイオ分子の経皮吸収促進
  • Solid-in-Oil (S/O)ギジュツ ト バイオ ブンシ ノ ケイヒ キュウシュウ ソクシン

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Description

<p>Biomolecules such as proteins or nucleic acids have been utilized as biopharmaceutical drugs, which produce various pharmacological activities. The development of a novel transdermal delivery system of biopharmaceuticals attracts much attention because it provides the easy and safe administration method compared to injection. The Solid-in-Oil (S/O) nanodispersion technique consists of the oil-based dispersion, in which the biopharmaceuticals are coated with hydrophobic surfactant molecules and dispersed in the oil phase as nanometer-sized particles. Insulin, a model pharmaceutical drug, enables to be dispersed in isopropyl myristate (IPM), that is known to be an effective skin penetration enhancer, by forming the S/O nanodispersion. The permeability of insulin into the skin was drastically enhanced. Further, the transdermal vaccination has been studied as one of the most important applications of the S/O nanodispersion. It was proved that the S/O nanodispersion containig a model antigen produced the antigen-specific antibodies and induced the cytotoxic cellular immunity in mouse. These results suggested that the S/O nanodispersion technique is useful for delivering biopharmaceuticals into the skin, and expected to become available in clinical.</p>

Journal

  • Oleoscience

    Oleoscience 22 (3), 121-126, 2022

    Japan Oil Chemists' Society

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