A favorable clinical course of acute myeloid leukemia with t (6;21;8)(p23;q22;q22)

  • WADA Atsushi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • DOKI Noriko
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • OTSUKA Yuki
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • ADACHI Hiroto
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • KONUMA Ryosuke
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • KISHIDA Yuya
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • KONISHI Tatsuya
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • YAMADA Yuta
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • NAGATA Akihito
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • NAGATA Ryohei
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • MARUMO Atsushi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • NOGUCHI Yuma
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • MUKAE Junichi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • TOYA Takashi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • IGARASHI Aiko
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • NAJIMA Yuho
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • KOBAYASHI Takeshi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • HARADA Hironori
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital Laboratory of Oncology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences
  • HARADA Yuka
    Clinical Research Support Center, Tokyo Metropolitan Cancer, and Infectious diseases Center Komagome Hospital
  • SAKAMAKI Hisashi
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital
  • OHASHI Kazuteru
    Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital

Bibliographic Information

Other Title
  • 良好な経過を辿ったt(6;21;8)(p23;q22;q22)を有する急性骨髄性白血病
  • リョウコウ ナ ケイカ オ タドッタ t(6;21;8)(p23;q22;q22)オ ユウスル キュウセイ コツズイセイ ハッケツビョウ

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Description

<p>Variants of the t (8;21) (q22;q22) involving chromosome 8, 21, and other chromosomes account for about 3% of all t (8;21) (q22;q22) in patients with acute myeloid leukemia (AML). However, the prognosis of AML with variant t (8;21) remains unknown due to the scarcity of reported cases. Herein we report a case of AML with t (6;21;8) (p23;q22;q22). Fluorescence in situ hybridization confirmed a RUNX1-RUNX1T1 fusion signal on the derivative chromosome 8. This is the first report on a variant of t (8;21) involving the breakpoint 6p23. After induction chemotherapy, our patient achieved complete remission and has been stable for four years.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 63 (2), 104-107, 2022

    The Japanese Society of Hematology

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