大阪に於ける牛のモノフロール酢酸ソーダ中毒に関する病理学的研究

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  • オオサカ ニ オケル ウシ ノ モノフロール サクサン ソーダ チュウドク ニ カンスル ビョウリガクテキ ケンキュウ
  • Pathological Studies on Sodium Monofluoroacetate Poisoning of Cattle in Osaka

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Since October of 1953 many cattle (Japanese black breed) died suddenly and successively in Higashiyodogawa-ku of Osaka and neighbouring Ajiu-mura. HASHIZUME et al. reported in the subjects of the occurrence, clinical symptoms and etiological survey. They suspected monofluoroacetic compounds as the causal agent, and succeeded to prove this assumption after the chemical examination. In this research we had chance to examine 16 field and 3 experimental cases pathologically (table 1 and 2). Chief pathological findings were as follows: 1) Tar-like findings and the incomplete coagulation of the blood. 2) Venous congestion and slight edema of the viscera, especially of the lungs. 3) Petechial hemorrhages of the thymus, lymph nodes, epicardium and tracheal mucosa. 4) Hydropic degeneration of the liver cells. 5) Myocardial degeneration and necrosis, especially of the papillary muscles of the left ventricle. 6) Venous congestion, edema and petechial hemorrhages of the brain; degeneration of nerve cells and slight proliferation of glia cells. Though the myocardial lesions were not so diffuse, and often only microscopic, they occurred frequently, chiefly in the type of fresh degenerate or necrotic foci without interstitial reaction (table 3). The papillary muscles of the left ventricle of 57 cattle slaughtered at Sakai Abattoir were examined as control, and slight lesions were found only in 5 cases (8.8%), showing far lower occurrence than field cases of this disease. The myocardial lesions were indistinct in the experimental cases (no. 1 and 2) which died shortly after the administration (2 and 8 houis respectively), but clearly seen in no. 3 which died 38 hours after the administration. So the development of them seemed to have significant relation to the length of subclinical period and dosis of the poison taken by cattle. Chief pathological findings of field materials agreeded with those of experimental cases except petechial hemorrhages of the thymus and lymph nodes which occurred very slightly in the latter. Thus we could not obtain any morphological findings which conflicted with the opinion that monofluoroacetic acid caused this sudden death. Generally speaking, there were scanty of distinct and characteristic lesion. But the findings of the heart and brain were thought to be significant, as these organs were known to be chiefly disturbed by monofluoroacetic acid.

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