Neural degeneration of auditory and hippocampal neurons in noise-induced hearing loss

  • Kurioka Takaomi
    Department of Otolaryngology, National Defense Medical College Department of Otolaryngology-Head and Neck Surgery, Kitasato University School of Medicine

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  • 音響性聴覚障害における蝸牛神経と海馬の障害メカニズムについて


<p>Cochlear hair cells (HCs) and auditory neurons (ANs) are often the primary site of cochlear damage induced by acoustic overstimulation, which often leads to secondary neural degeneration in ANs after HC loss and suppresses hippocampal neurogenesis, resulting in cognitive decline. However, it is unclear whether the loss of HCs or decreasing auditory inputs alone causes secondary degeneration in ANs and hippocampal neurogenesis. Selective HC ablation and noise exposure have shown different patterns of pathology in the auditory pathway, in which decreasing auditory inputs from selective HC loss or conductive hearing loss led to secondary neural degeneration in ANs and hippocampal neurogenesis. Furthermore, auditory deprivation could lead to increased microglial invasion and stress responses, which might be a risk factor for hippocampal neurogenesis impairment. Therefore, auditory activities are required to maintain the fundamental functions of ANs and hippocampus.</p>


  • Otology Japan

    Otology Japan 31 (3), 235-239, 2021

    Japan Otological Society

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    • KAKEN
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