The effect of intratracheal administration of thyroid hormone (T<sub>3</sub>) in chronic obstructive pulmonary disease (COPD) mouse model simulating disease type classification.
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- Takahashi Noriki
- Dept. Mol. Med. Kumamoto Uinv. HIGO Program Kumamoto Univ.
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- Nakashima Ryunosuke
- Dept. Mol. Med. Kumamoto Uinv.
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- Nasu Aoi
- Dept. Mol. Med. Kumamoto Uinv. HIGO Program Kumamoto Univ.
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- Hayashi Megumi
- Dept. Mol. Med. Kumamoto Uinv.
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- Kishimoto Tomoki
- Dept. Mol. Med. Kumamoto Uinv.
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- Suico Mary Ann
- Dept. Mol. Med. Kumamoto Uinv.
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- Kai Hirofumi
- Dept. Mol. Med. Kumamoto Uinv.
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- Shuto Tsuyoshi
- Dept. Mol. Med. Kumamoto Uinv.
Bibliographic Information
- Other Title
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- 病型分類を模擬した慢性閉塞性肺疾患(COPD)モデル動物に対する甲状腺ホルモン(T<sub>3</sub>)経気管投与の影響
Abstract
<p>【Purpose】</p><p>COPD is a refractory pulmonary disease characterized by bronchitis, emphysema and mucus stasis. Because COPD is a multifactorial disease and represents various symptoms for each patient, previous studies which regard COPD as a single disease have limits. Therefore, to establish personalized medicine for COPD we need research developments based on phenotype or endotype classification. Here, I focused on T3 which has long been known to act as an essential factor for development and growth in the lung. This study aims to elucidate the pathophysiological role of T3 using COPD mouse model simulating disease type classification (emphysema- or airway-dominant). </p><p>【Methods & results】</p><p>In this study, I chose elastase-induced model and C57BL/6-βENaC-Tg mice as mouse models of emphysema- and airway-dominant COPD, respectively. I intratracheally administered T3 (40 or 80 μg/kg, every other day) to elastase-induced mice for 21 days or C57BL/6-βENaC-Tg mice for 12 days. In elastase-induced model, T3 treatment improved emphysema and, partially, the respiratory function with upregulation of the expression of Ppargc1a (the master regulator of mitochondrial biogenesis) and Gclm (an oxidative stress-related factor) after one T3 injection. On the other hand, in C57BL/6-βENaC-Tg mice T3 treatment did not improve COPD pathology.</p><p>【Discussion】</p><p>These results emphasize the importance of research developments based on phenotype or endotype classification considering that T3 effect is different between two COPD models.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 95 (0), 1-SS-59-, 2022
Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390010292718367744
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
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- Abstract License Flag
- Disallowed