A case of multiple systemic thrombosis including cerebral infarction associated with SARS-CoV-2, in which PCR test for SARS-CoV-2 was negative but antibody test was positive

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  • 脳梗塞を含む全身性多発血栓症を来し，SARS-CoV-2 PCR検査複数回陰性も後に抗体陽性が判明した1例

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<p>In a healthy 61-year-old man, on September X, 2020 (day of onset 0), general malaise and respiratory distress were observed. On the 7th day after onset, COVID-19 pneumonia was suspected on chest CT, and the patient was transferred to the emergency department of our center for hospitalization, but the SARS-CoV-2 PCR test was negative. On the 8th day after onset, his response became ambiguous, and right hemiparesis appeared on the 10th day after onset, so the patient immediately consulted our stroke center. Left M1 occlusion was observed by CTA, and the recanalization was obtained by emergency mechanical thrombectomy. On the 11th day, renal function deteriorated, and contrast-enhanced CT showed occlusion of the right renal and hepatic arteries, thrombus on the aortic wall, and splenic infarction. Endovascular treatment was performed for right renal artery occlusion. All four PCR tests up to the 12th day were negative, but the SARS-CoV-2 antibody test on the 14th day after onset was positive for both IgG and IgM.We will report the case diagnosed as COVID-19-related thrombosis because it showed a characteristic pneumonia image and the antibody test was positive after developing systemic arterial thrombosis including cerebral infarction, although the PCR test was negative multiple times.</p>

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