プラズモン共鳴を利用した培養軟骨摩擦における接触面評価システムの開発

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  • Development of the evaluation system for contact area of tissue-engineered cartilage during friction by using surface plasmon resonance

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<p>A variety of glycoproteins and lipids are expressed and adsorbed on the surface of articular cartilage. And these molecules play an important role in the cartilage lubrication function. However, the effects of the molecular distribution and the changes in their local interactions at the cartilage contact interface on the lubrication property have not been clarified yet. In this study, we developed an optical system that can detect changes in the molecular distribution and interactions at the contact interface of tissue-engineered cartilage during friction by using surface plasmon resonance (SPR), which can detect molecular interactions near the contact surface. By using a variable laser incidence angle mechanism, it is possible to scan the resonance angle, which changes with molecular species and interactions during friction. In this study, we evalulated the lubrication properties of agarose gel and agarose-chondrocyte complex material with observing the contact interface using the optical system. In the comparison of the contact state at the agarose specific incidence angle, it was confirmed that the region of SPR at the contact interface of the agarose-chondrocyte complex material clearly decreased. As a result, we can successfully detect the time-dependent changes in the relation between the contact state and the lubrication property of tissue-engineered cartilate tissue.</p>

収録刊行物

  • 年次大会

    年次大会 2021 (0), J302-09-, 2021

    一般社団法人 日本機械学会

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