Detection of Group A Rotavirus RNA and Antigens in Serum and Cerebrospinal Fluid from Two Children with Clinically Mild Encephalopathy with a Reversible Splenial Lesion

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  • Arakawa Chikako
    Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan
  • Fujita Yukihiko
    Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan
  • Imai Yuki
    Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan
  • Ishii Wakako
    Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan
  • Kohira Ryutaro
    Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan
  • Fuchigami Tatsuo
    Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan
  • Mugishima Hideo
    Department of Pediatrics and Child Health, Nihon University School of Medicine, Japan
  • Izumi Hiroyuki
    Division of Pediatrics, Itabashi Medical Association Hospital, Japan
  • Kuzuya Mitsutaka
    Department of Virology, Okayama Prefectural Institute for Environmental Science and Public Health, Japan

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<p>We report on two children with mild encephalopathy with a reversible splenial lesion associated with group A rotavirus (GARV) infection. We examined stool, serum, and cerebrospinal fluid samples to determine the presence of the GARV VP7 gene and GARV antigen by reverse-transcription PCR and enzyme-linked immunosorbent assay, respectively. GARV antigen was detected in stool samples from both patients. The GARV G genotype was G9 in one child and G3 in the other. GARV antigens were also found in both serum samples. However, the GARV VP7 gene was detected in only one serum sample, which was collected on the first day of symptomatic illness. Neither GARV antigen nor the VP7 gene was detected in cerebrospinal fluid samples. Both patients had excellent outcomes. Our results suggest that the reversible splenial changes in our patients might have been caused by indirect effects to the central nervous system subsequent to viral infection.<tt> </tt></p>

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