Molecular Epidemiology of Trichophyton tonsurans Strains Isolated in Japan between 2006 and 2010 and Their Susceptibility to Oral Antimycotics

DOI Web Site Web Site 被引用文献3件
  • Anzawa Kazushi
    Department of Dermatology, Research Institute of Medical Science, Kanazawa Medical University, Japan Division of Dermatomycology (Novartis Pharma), Research Institute of Medical Science, Kanazawa Medical University, Japan
  • Mochizuki Takashi
    Department of Dermatology, Research Institute of Medical Science, Kanazawa Medical University, Japan Division of Dermatomycology (Novartis Pharma), Research Institute of Medical Science, Kanazawa Medical University, Japan
  • Nishibu Akiko
    Department of Dermatology, Research Institute of Medical Science, Kanazawa Medical University, Japan
  • Ishizaki Hiroshi
    Division of Dermatomycology (Novartis Pharma), Research Institute of Medical Science, Kanazawa Medical University, Japan
  • Kamei Katsuhiko
    Division of Fungal Infection, Medical Mycology Research Center, Chiba University, Japan
  • Takahashi Yoko
    Division of Fungal Infection, Medical Mycology Research Center, Chiba University, Japan
  • Fujihiro Machiko
    Department of Dermatology, Ibi Welfare Hospital, Japan
  • Shinoda Hidekazu
    Shinoda Dermatological Clinic, Japan

書誌事項

タイトル別名
  • Molecular Epidemiology of <i>Trichophyton tonsurans</i> Strains Isolated in Japan between 2006 and 2010 and Their Susceptibility to Oral Antimycotics

この論文をさがす

抄録

<p>Trichophyton tonsurans has been isolated among judo practitioners, wrestlers, and sumo wrestlers during an epidemic of tinea corporis and tinea capitis in Japan. A previous study using restriction fragment length polymorphism (RFLP) analysis of the non-transcribed spacer (NTS) region of the ribosomal RNA gene revealed that different sources for the causative fungus in epidemics among judo practitioners and among wrestlers. Many different fungal strains have since been isolated from practitioners of these sports. The present study evaluated fungal characteristics of strains newly isolated between July 2006 and December 2010 using this molecular method. PCR-RFLP analysis using MvaI and AvaI was performed on 263 strains, composed of 186 isolates from judo practitioners, 32 from wrestlers, 30 from sumo wrestlers, 5 from other sports, 7 from family members or friends of the sports practitioner patients, and 3 from sporadic (non-epidemic) cases. Four molecular types, NTS I, II, III, and VII were detected. Of these, NTS I was the most predominant, occurring in 243 of 263 strains (92.4%). All of the 30 strains isolated from sumo wrestlers were classified as NTS I, suggesting that the epidemic among sumo wrestlers originated from an earlier epidemic among judo practitioners. Thirteen strains were classified as NTS II; all were related to wrestling and were isolated mainly from Chubu and Kansai areas in the central part of Honshu island. NTS III was detected in 6 strains, and one strain classified as NTS VII was isolated from a sporadic case of tinea capitis in a Peruvian immigrant. The minimum inhibitory concentrations (MICs) of terbinafine, itraconazole, fluconazole, and griseofulvin on 10 strains of NTS I and NTS II and 4 strains of NTS III were examined; there were no differences in MIC between these molecular types.<tt> </tt></p>

収録刊行物

被引用文献 (3)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ